How Fat Kills Insulin-Producing Beta Cells

1. Boden G. Fatty acid-induced irritation and insulin resistance in skeletal muscle and liver. Curr Diab Rep. 2006 Jun;6(Three):177–81.

2. Boden G. Role of fatty acids within the pathogenesis of insulin resistance and NIDDM. Diabetes. 1997 Jan;46(1):Three–10.

Three. Boden G, Shulman GI. Free fatty acids in weight problems and sort 2 diabetes: defining their function within the growth of insulin resistance and β-cell dysfunction. Eur J Clin Invest. 2002 Jun 1;32:14–23.

four. Boden G. Fatty acid-induced irritation and insulin resistance in skeletal muscle and liver. Curr Diab Rep. 2006 Jun;6(Three):177–81.

5. Boden G, Shulman GI. Free fatty acids in weight problems and sort 2 diabetes: defining their function within the growth of insulin resistance and β-cell dysfunction. Eur J Clin Invest. 2002 Jun 1;32:14–23.

6. Itani SI, Ruderman NB, Schmieder F, Boden G. Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α. Diabetes. 2002 Jul 1;51(7):2005–11.

7. Savage DB, Petersen KF, Shulman GI. Disordered Lipid Metabolism and the Pathogenesis of Insulin Resistance. Physiol Rev. 2007 Apr 1;87(2):507–20.

eight. Xiao C, Giacca A, Carpentier A, Lewis GF. Differential results of monounsaturated, polyunsaturated and saturated fats ingestion on glucose-stimulated insulin secretion, sensitivity and clearance in obese and overweight, non-diabetic people. Diabetologia. 2006 Apr 5;49(6):1371–9.

9. Wang P-Y, Kaneko T, Wang Y, Tawata M, Sato A. Impairment of Glucose Tolerance in Normal Adults Following a Lowered Carbohydrate Intake. Tohoku J Exp Med. 1999;189(1):59–70.

10. Martins AR, Nachbar RT, Gorjao R, Vinolo MA, Festuccia WT, Lambertucci RH, et al. Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: significance of the mitochondrial perform. Lipids Health Dis. 2012;11:30.

11. Delarue J, Magnan C. Free fatty acids and insulin resistance. Curr Opin Clin Nutr Metab Care. 2007 Mar;10(2):142–eight.

12. Griffin ME, Marcucci MJ, Cline GW, Bell Okay, Barucci N, Lee D, et al. Free fatty acid-induced insulin resistance is related to activation of protein kinase C theta and alterations within the insulin signaling cascade. Diabetes. 1999 Jun;48(6):1270–four.

13. Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol Three-kinase exercise in muscle. J Biol Chem. 2002 Dec 27;277(52):50230–6.

14. Hirabara SM, Curi R, Maechler P. Saturated fatty acid-induced insulin resistance is related to mitochondrial dysfunction in skeletal muscle cells. J Cell Physiol. 2010 Jan;222(1):187–94.

15. Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest. 2000 Jul;106(2):171–6.

16. Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, Cline GW, et al. Mechanism of free fatty acid-induced insulin resistance in people. J Clin Invest. 1996 Jun 15;97(12):2859–65.

17. Silveira LR, Fiamoncini J, Hirabara SM, Procópio J, Cambiaghi TD, Pinheiro CHJ, et al. Updating the results of fatty acids on skeletal muscle. J Cell Physiol. 2008 Oct;217(1):1–12.

18. Roden M. How free fatty acids inhibit glucose utilization in human skeletal muscle. News Physiol Sci Int J Physiol Prod Jointly Int Union Physiol Sci Am Physiol Soc. 2004 Jun;19:92–6.

19. Galgani JE, Moro C, Ravussin E. Metabolic flexibility and insulin resistance. Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1009-1017.

20. Yamamoto Noguchi CC, Kunikane N, Hashimoto S, Furutani E. Mixed mannequin of dietary fats impact on postprandial glucose-insulin metabolism from carbohydrates in sort 1 diabetes. Conf Proc Annu Int Conf IEEE Eng Med Biol Soc IEEE Eng Med Biol Soc Annu Conf. 2015 Aug;2015:8058–61.

21. Sumiyoshi M, Sakanaka M, Kimura Y. Chronic Intake of High-Fat and High-Sucrose Diets Differentially Affects Glucose Intolerance in Mice. J Nutr. 2006 Mar 1;136(Three):582–7.

22. Taylor R. Banting Memorial lecture 2012: reversing the dual cycles of sort 2 diabetes. Diabet Med J Br Diabet Assoc. 2013 Mar;30(Three):267–75.

23. Pańkowska E, Błazik M, Groele L. Does the fat-protein meal improve postprandial glucose degree in sort 1 diabetes sufferers on insulin pump: the conclusion of a randomized examine. Diabetes Technol Ther. 2012 Jan;14(1):16–22.

24. Smart CEM, Evans M, O’Connell SM, McElduff P, Lopez PE, Jones TW, et al. Both dietary protein and fats improve postprandial glucose excursions in kids with sort 1 diabetes, and the impact is additive. Diabetes Care. 2013 Dec;36(12):3897–902.

25. Paterson M, Bell KJ, O’Connell SM, Smart CE, Shafat A, King B. The Role of Dietary Protein and Fat in Glycaemic Control in Type 1 Diabetes: Implications for Intensive Diabetes Management. Curr Diab Rep. 2015 Jul 23;15(9):1–9.

26. Neu A, Behret F, Braun R, Herrlich S, Liebrich F, Loesch-Binder M, et al. Higher glucose concentrations following protein- and fat-rich meals – the Tuebingen Grill Study: a pilot examine in adolescents with sort 1 diabetes. Pediatr Diabetes. 2015 Dec 1;16(eight):587–91.

27. Haber EP, Ximenes HMA, Procópio J, Carvalho CRO, Curi R, Carpinelli AR. Pleiotropic results of fatty acids on pancreatic beta-cells. J Cell Physiol. 2003 Jan;194(1):1–12.

28. Haber EP, Procópio J, Carvalho CRO, Carpinelli AR, Newsholme P, Curi R. New insights into fatty acid modulation of pancreatic beta-cell perform. Int Rev Cytol. 2006;248:1–41.

29. Kraegen EW, Cooney GJ, Ye JM, Thompson AL, Furler SM. The function of lipids within the pathogenesis of muscle insulin resistance and beta cell failure in sort II diabetes and weight problems. Exp Clin Endocrinol Diabetes Off J Ger Soc Endocrinol Ger Diabetes Assoc. 2001;109 Suppl 2:S189-201.

30. Kusminski CM, Shetty S, Orci L, Unger RH, Scherer PE. Diabetes and apoptosis: lipotoxicity. Apoptosis Int J Program Cell Death. 2009 Dec;14(12):1484–95.

31. Manco M, Calvani M, Mingrone G. Effects of dietary fatty acids on insulin sensitivity and secretion. Diabetes Obes Metab. 2004 Nov;6(6):402–13.

32. Poitout V, Robertson RP. Minireview: Secondary beta-cell failure in sort 2 diabetes–a convergence of glucotoxicity and lipotoxicity. Endocrinology. 2002 Feb;143(2):339–42.

33. Robertson RP, Harmon J, Tran POT, Poitout V. β-Cell Glucose Toxicity, Lipotoxicity, and Chronic Oxidative Stress in Type 2 Diabetes. Diabetes. 2004 Feb 1;53(suppl 1):S119–24.

34. Sharma RB, Alonso LC. Lipotoxicity within the pancreatic beta cell: not simply survival and performance, however proliferation as properly? Curr Diab Rep. 2014 Jun;14(6):492.

35. Shimabukuro M, Zhou YT, Levi M, Unger RH. Fatty acid-induced beta cell apoptosis: a hyperlink between weight problems and diabetes. Proc Natl Acad Sci U S A. 1998 Mar Three;95(5):2498–502.

36. Unger RH, Grundy S. Hyperglycaemia as an inducer in addition to a consequence of impaired islet cell perform and insulin resistance: implications for the administration of diabetes. Diabetologia. 1985 Mar;28(Three):119–21.

37. Unger RH, Zhou YT. Lipotoxicity of beta-cells in weight problems and in different causes of fatty acid spillover. Diabetes. 2001 Feb;50 Suppl 1:S118-121.

38. Unger RH. Lipotoxicity within the pathogenesis of obesity-dependent NIDDM. Genetic and medical implications. Diabetes. 1995 Aug;44(eight):863–70.

39. Cnop M, Hughes SJ, Igoillo-Esteve M, Hoppa MB, Sayyed F, van de Laar L, et al. The lengthy lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation. Diabetologia. 2010 Feb;53(2):321–30.

40. Cheng C, Villani V, Buono R, Wei M, Kumar S, Yilmaz O, Cohen P, Sneddon J, Perin L, Longo V. Fasting-mimicking weight-reduction plan promotes ngn3-driven b-cell regeneration to reverse diabetes. Cell. 2017 Feb; 168(5): 775-88.