More members on the DUAL VII trial preferred to keep on Xultophy remedy in contrast to therapy with bolus and basal injections, and had enhancements in psychological well being.
Xultophy is a once-daily single mixture injection of Tresiba (long-acting insulin degludec) and Victoza (liraglutide), a GLP-1 agonist. The drug, developed by Novo Nordisk, is designed to deal with individuals with type 2 diabetes who’ve been unable to management blood sugar ranges on different remedies.
Researchers monitored 506 adults with type 2 diabetes from 12 international locations, who had been both assigned Xultophy or basal-bolus remedy for 26 weeks. Prior to the study all members had poorly managed blood sugar ranges on Lantus (insulin glargine) and metformin.
The members had been requested to full a questionnaire after the trial to assess patient-related outcomes (PROs). Xultophy was considerably related to higher experiences for psychological well being, whereas different enhancements included remedy burden and compliance.
Xultophy led to equal reductions in HbA1c, decrease charges of hypoglycemia, fewer injections per day and higher weight reduction, in contrast to these on a number of every day injections.
Mads Krogsgaard Thomsen, government vice chairman and chief science officer of Novo Nordisk, mentioned: “Living with diabetes is a complex situation in itself, and the treatment should not add to this. We are very pleased to see that Xultophy not only helps people with type 2 diabetes reach their blood glucose targets while reducing the risk of hypoglycemia and helping them to lose weight, but does this in a simple way.”
The findings have been introduced on the 2017 International Diabetes Federation Congress in Abu Dhabi, UAE.
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